Chemical Valley came into prominence during the Second World War. Supplies of rubber from the Far East were cut off, and so quantities for making airplane and truck tires were running out. A new synthetic rubber plant was built in Sarnia to combat the lack of imported natural rubber. Sarnia was chosen for both its proximity to Imperial Oil and its status as a transportation hub to the United States, including being far enough inland that it was not an easy target. It is widely theorized that without the rubber plant in Sarnia, the Allies may not have been as successful in the war.
The Goverment of Canada instituted the War Measures Act during World War II. The land at Stoney Point became a casualty of war for the Native population, a land claim that is still not settled today.